A drug called tesamorelin makes belly fat shrink by 11% in 6 months, while fake pills barely change anything.
Scientific Claim
Administration of tesamorelin results in a statistically significant reduction in visceral adipose tissue volume compared to placebo, with a mean reduction of approximately 11% after 6 months of treatment.
Original Statement
“Visceral fat decreased by nearly 11% in the tesamorelin group. Okay, this was compared to less than 1% in the placebo group. Waist circumference went down, trunk fat went down, IGF levels went up...”
Context Details
Domain
pharmacology
Population
human
Subject
Tesamorelin
Action
reduces
Target
visceral adipose tissue volume
Intervention Details
Evidence from Studies
Supporting (3)
Unknown Title
In a well-run study, people with HIV who took tesamorelin lost about 11% of their dangerous belly fat in 6 months, while those on a dummy pill lost almost none — proving the drug works.
1499. Tesamorelin Reduces Visceral Adipose Tissue and Liver Fat in INSTI-Treated Persons with HIV
This study shows that giving tesamorelin to people with HIV helps shrink the dangerous belly fat, which is exactly what the claim says.
Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV
This study confirms that tesamorelin shrinks belly fat in HIV patients — the exact thing the claim is about.