The Claim
In patients with ST-elevation myocardial infarction, polyphenol supplementation is associated with an increased abundance of Sellimonas and Agathobaculum species, which are butyrate-producing taxa linked to gut homeostasis and competitive inhibition of TMAO-producing bacteria.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In people who have had a heart attack called STEMI, taking polyphenol supplements is linked to higher levels of two gut bacteria, Sellimonas and Agathobaculum, that produce butyrate and are associated with reduced activity of bacteria that make TMAO.
See the scientific wording
In STEMI patients, polyphenol supplementation is associated with increased abundance of Sellimonas and Agathobaculum sp., both butyrate-producing taxa, which are linked to gut homeostasis and may competitively inhibit TMAO-producing bacteria.
Polyphenols feed specific gut bacteria that make butyrate, which strengthens the gut lining. These bacteria grow faster than harmful ones that produce TMAO, pushing them out. With fewer harmful bacteria and a tighter gut barrier, fewer toxins enter the blood, so the liver makes less TMAO.
What the research says
1 studyStudy: Polyphenol-mediated microbiome modulation in STEMI patients: a pilot study
After a heart attack, people who took polyphenol supplements had more of two helpful gut bacteria—Sellimonas and Agathobaculum—that make butyrate and may block harmful bacteria linked to heart disease. The study found this directly in patients who took the supplements.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.