After damaging the inner optic nerve head tissue with enzymes, adding saline solution slightly increased stiffness by about 13% compared to the damaged state.
Scientific Claim
In rat glial lamina tissue, vehicle treatment after MMP-1 damage is associated with a 13.2% increase in Young's modulus compared to MMP-1-damaged tissue.
Original Statement
“Although stiffness increased by 13.2% with application of the vehicle (Figure 2C, Table 2), it did not increase the stiffness of the tissue to the same magnitude as observed with CMP-3.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design is treated as non-causal evidence per GRADE analysis, so using 'associated with' is appropriate. The specific percentage change is accurately reported from the data.
Evidence from Studies
Supporting (1)
Collagen Mimetic Peptides Promote Repair of MMP-1-Damaged Collagen in the Rodent Sclera and Optic Nerve Head