After damaging the inner optic nerve head tissue with enzymes, the special peptide restored stiffness by nearly 50% compared to the damaged state.

Scientific Claim

In rat glial lamina tissue, collagen mimetic peptide-3 (CMP-3) treatment after MMP-1 damage is associated with a 49.5% increase in Young's modulus compared to MMP-1-damaged tissue.

Original Statement

“CMP-3 again partially restored stiffness of the tissue (49.5% increase; Figure 2C, Table 2).”

From study:Collagen Mimetic Peptides Promote Repair of MMP-1-Damaged Collagen in the Rodent Sclera and Optic Nerve Head

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design is treated as non-causal evidence per GRADE analysis, so using 'associated with' is appropriate. The specific percentage change is accurately reported from the data.

Evidence from Studies

Supporting (1)

Collagen Mimetic Peptides Promote Repair of MMP-1-Damaged Collagen in the Rodent Sclera and Optic Nerve Head

Cohort Study

Animal

2023 Dec 1

Contradicting (0)

No contradicting evidence found

Source Study

Collagen Mimetic Peptides Promote Repair of MMP-1-Damaged Collagen in the Rodent Sclera and Optic Nerve Head

Score: 12

DOI: 10.3390/ijms242317031

Similar Assertions

After damaging the eye tissue with collagen-breaking enzymes, applying a special peptide helped restore some stiffness, increasing it by about 23% compared to the damaged state.

87%

After damaging the inner optic nerve head tissue with enzymes, adding saline solution slightly increased stiffness by about 13% compared to the damaged state.

82%

After damaging the eye tissue with enzymes, the special peptide reduced broken collagen levels compared to a saline solution, as seen with a fluorescent marker.

78%

In the inner part of the eye's optic nerve head, collagen-breaking enzymes caused a 57% drop in stiffness compared to normal.

77%