After damaging the eye tissue with collagen-breaking enzymes, applying a special peptide helped restore some stiffness, increasing it by about 23% compared to the damaged state.
Scientific Claim
In rat peripapillary sclera tissue, collagen mimetic peptide-3 (CMP-3) treatment after MMP-1 damage is associated with a 23.0% increase in Young's modulus compared to MMP-1-damaged tissue.
Original Statement
“CMP-3 reversed this trend, increasing the average Young’s modulus by 23.0% (Figure 1C, Table 1), signifying at least a partial restoration of PPS stiffness.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design is treated as non-causal evidence per GRADE analysis, so using 'associated with' is appropriate. The specific percentage change is accurately reported from the data.
Evidence from Studies
Supporting (1)
Collagen Mimetic Peptides Promote Repair of MMP-1-Damaged Collagen in the Rodent Sclera and Optic Nerve Head