After starting dapagliflozin, the kidneys produced more aldosterone hormone for a few days, which might help the body retain salt, but this effect didn't last after two weeks.

As expected, dapagliflozin caused people with type 2 diabetes to excrete much more sugar in their urine, which is how the drug works to lower blood sugar.

Even though dapagliflozin lowered blood pressure, it didn't cause people with type 2 diabetes and healthy kidneys to excrete more salt in their urine when they ate a controlled amount of salt.

Dapagliflozin didn't significantly change the amount of fluid in the bloodstream of people with type 2 diabetes and healthy kidneys, even after two weeks of treatment.

Taking dapagliflozin for two weeks lowered blood pressure by about 6-7 points in people with type 2 diabetes and healthy kidneys, even when they ate a controlled amount of salt.

Dapagliflozin caused a temporary decrease in body fluid volume outside cells after 4 days, but this effect went away after two weeks in people with type 2 diabetes and healthy kidneys.