Taking dapagliflozin for two weeks lowered blood pressure by about 6-7 points in people with type 2 diabetes and healthy kidneys, even when they ate a controlled amount of salt.
Scientific Claim
In patients with type 2 diabetes and preserved kidney function on a standardized sodium intake of 150 mmol/day, dapagliflozin treatment was associated with a reduction in 24-hour systolic blood pressure of 6.1 mmHg (95% CI: -9.1 to -3.1) after 2-4 days and 7.2 mmHg (95% CI: -10.0 to -4.3) after 12-14 days of treatment.
Original Statement
“Mean baseline 24-h systolic blood pressure was 128 (10) mmHg and significantly reduced at ST (−6.1 mmHg [−9.1, −3.1]; P < 0.001) and ET (−7.2 mmHg [−10.0, −4.3]; P < 0.001).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design is nonrandomized and lacks a control group, so only association can be inferred. The claim correctly uses 'associated with' to reflect this limitation.