People with type 2 diabetes and healthy kidneys lost about 0.8 kg after a few days and 1.8 kg after two weeks of taking dapagliflozin, likely due to water loss.
Scientific Claim
Dapagliflozin treatment was associated with a reduction in body weight of 0.8 kg (95% CI: -1.2 to -0.5) after 2-4 days and 1.8 kg (95% CI: -2.5 to -1.1) after 12-14 days in patients with type 2 diabetes and preserved kidney function on a standardized sodium intake.
Original Statement
“Mean (SD) body weight at baseline was 98.7 (15.9) kg, which was significantly reduced during dapagliflozin treatment (mean change at ST: −0.8 kg [95% CI −1.2, −0.5; P < 0.001]; mean change at ET: −1.8 kg [−2.5, −1.1; P < 0.001]).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design is nonrandomized and lacks a control group, so only association can be inferred. The claim correctly uses 'associated with' to reflect this limitation.