The Claim

Daily supplementation with vitamin D3 (5000 IU), vitamin K2 (100 μg), vitamin B6 (2.5 mg), vitamin B12 (1000 μg), and magnesium (75 mg) for twelve weeks in middle-aged women (aged 45–63) with suboptimal micronutrient intake is associated with a 4.0% reduction in fasting glucose, a 6.5% reduction in total cholesterol, and a 24.1% reduction in homocysteine.

Source: Effects of 12-Week Multiple Micronutrient Supplementation on Immune Function, Body Weight, and Metabolic Parameters in Middle-Aged Women: A Retrospective Study

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
40score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

In middle-aged women with low micronutrient levels, taking a daily supplement of vitamin D3, vitamin K2, vitamin B6, vitamin B12, and magnesium for twelve weeks is associated with lower fasting glucose, lower total cholesterol, and lower homocysteine levels.

See the scientific wording

Twelve weeks of daily supplementation with vitamin D3 (5000 IU), vitamin K2 (100 μg), vitamin B6 (2.5 mg), vitamin B12 (1000 μg), and magnesium (75 mg) in middle-aged women (aged 45–63) with suboptimal micronutrient intake is associated with a 4.0% reduction in fasting glucose, a 6.5% reduction in total cholesterol, and a 24.1% reduction in homocysteine.

Why this might work

Magnesium and B vitamins work together to break down homocysteine, which reduces damage to blood vessels and improves how the body uses insulin. This lets muscles take in more sugar from the blood, lowering blood sugar levels. Magnesium also helps the liver remove cholesterol from the blood by packaging it into HDL particles for disposal. Vitamin K2 prevents calcium from building up in artery walls, which stops bad cholesterol from getting trapped and oxidized, making it easier for the liver to clear it from the blood.

Verified mechanismbased on 1 study

What the research says

1 study

  1. Study: Effects of 12-Week Multiple Micronutrient Supplementation on Immune Function, Body Weight, and Metabolic Parameters in Middle-Aged Women: A Retrospective Study

    This study found that when middle-aged women took this specific mix of vitamins and magnesium every day for 12 weeks, their blood sugar, cholesterol, and homocysteine levels all went down — just like the claim said.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

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