After taking a 240 mg oral dose, cocrystal ubiquinol produces 3.4 times more total CoQ10 in the bloodstream over time than ubiquinone in healthy adults aged 45–65, resulting in higher absorption and...
Mechanism
Synthesis from 1 study
The special crystal form keeps CoQ10 from breaking down in the gut, so more of it gets absorbed as the active version without needing to be changed first. This leads to much higher and longer-lasting levels in the blood.
Most probable mechanism
A special crystal structure protects the active form of CoQ10 from breaking down in the gut, allowing more of it to be absorbed directly into the blood without needing to be converted from another form, leading to higher and longer-lasting levels in the body.
The cocrystal structure of ubiquinol with nicotinamide prevents oxidative degradation of ubiquinol in the gastrointestinal lumen during digestion.
Intact ubiquinol molecules cross the intestinal epithelium more efficiently than ubiquinone due to higher solubility and membrane permeability.
Absorbed ubiquinol enters systemic circulation without requiring enzymatic conversion from ubiquinone, avoiding a rate-limiting metabolic step that is inefficient in adults over 45.
Plasma ubiquinol is partially oxidized to ubiquinone during sample handling, but the total measured concentration reflects the initial absorbed dose of ubiquinol.
Evidence from Studies
Supporting (1)
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