The Claim

Daily supplementation with vitamin D3 (5000 IU), vitamin K2 (100 μg), vitamin B6 (2.5 mg), vitamin B12 (1000 μg), and magnesium (75 mg) for twelve weeks in middle-aged women (aged 45–63) with suboptimal micronutrient intake is associated with a significant reduction in LDL cholesterol without changes in HDL cholesterol or triglycerides.

Source: Effects of 12-Week Multiple Micronutrient Supplementation on Immune Function, Body Weight, and Metabolic Parameters in Middle-Aged Women: A Retrospective Study

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
40score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

In middle-aged women with low micronutrient levels, taking a daily supplement of vitamin D3, vitamin K2, vitamin B6, vitamin B12, and magnesium for twelve weeks is linked to lower LDL cholesterol without affecting HDL cholesterol or triglycerides.

See the scientific wording

Twelve weeks of daily supplementation with vitamin D3 (5000 IU), vitamin K2 (100 μg), vitamin B6 (2.5 mg), vitamin B12 (1000 μg), and magnesium (75 mg) in middle-aged women (aged 45–63) with suboptimal micronutrient intake is associated with a significant reduction in LDL cholesterol without changes in HDL cholesterol or triglycerides.

Why this might work

Vitamin K2 activates a protein that prevents calcium from building up in artery walls, which reduces damage to LDL particles and helps the liver remove them from the blood. Magnesium increases the activity of a transporter that pulls cholesterol out of artery walls and delivers it to the liver for disposal, lowering LDL levels without affecting good cholesterol.

Verified mechanismbased on 1 study

What the research says

1 study

  1. Study: Effects of 12-Week Multiple Micronutrient Supplementation on Immune Function, Body Weight, and Metabolic Parameters in Middle-Aged Women: A Retrospective Study

    This study gave middle-aged women the exact same vitamins and magnesium as the claim, and after 12 weeks, their overall bad cholesterol went down without any increase in good cholesterol or fats — which means the supplement likely lowered the bad kind specifically.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.