When rats were given a special version of hyaluronic acid by mouth, almost all of it left their bodies within a week through breathing, pee, and poop—very little stayed inside, so it didn’t build up.

When rats were given a special version of hyaluronic acid (a substance found in joints), most of it turned into carbon dioxide and was breathed out within a week, meaning their livers broke it down completely.

When rats ate hyaluronic acid, only 16% of it made it into their bloodstream unchanged — the rest got broken down or didn’t get absorbed at all.

When rats swallow a special kind of big molecule labeled with a traceable marker, most of it comes out in their poop within two days — like 9 out of 10 pieces or more.

If you give female mice a special kind of hyaluronic acid pill every day for a week, their bodies end up with more of this substance in their blood and several organs like their skin, eyes, and bladder.