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Dietary Hyaluronic Acid Migrates into the Skin of Rats
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Skin radioactivity exceeded blood levels at 24 and 96 hours
Most assume if something enters the bloodstream, it’s highest there—but here, skin held onto the signal longer, suggesting targeted delivery or retention of fragments.
Practical Takeaways
If you take HA supplements, don’t expect miracles—but don’t toss them out either. They may be broken into skin-friendly fragments.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Skin radioactivity exceeded blood levels at 24 and 96 hours
Most assume if something enters the bloodstream, it’s highest there—but here, skin held onto the signal longer, suggesting targeted delivery or retention of fragments.
Practical Takeaways
If you take HA supplements, don’t expect miracles—but don’t toss them out either. They may be broken into skin-friendly fragments.
Publication
Journal
The Scientific World Journal
Year
2014
Authors
Mariko Oe, K. Mitsugi, Wataru Odanaka, Hideto Yoshida, Ryosuke Matsuoka, Satoshi Seino, T. Kanemitsu, Y. Masuda
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Claims (6)
When rats were given a special version of hyaluronic acid by mouth, scientists found traces of it in their skin two days and four days later—and even more was in the skin than in the blood, which means the substance traveled through the body and reached the skin.
When rats were given a special version of hyaluronic acid (a substance found in joints), most of it turned into carbon dioxide and was breathed out within a week, meaning their livers broke it down completely.
When rats were given a special version of hyaluronic acid by mouth, almost all of it left their bodies within a week through breathing, pee, and poop—very little stayed inside, so it didn’t build up.
When rats were given a special version of hyaluronic acid by mouth, their blood showed the highest level of radioactivity after 8 hours, which means the substance took a long time to get from their stomach into their bloodstream.
When rats ate hyaluronic acid, only 16% of it made it into their bloodstream unchanged — the rest got broken down or didn’t get absorbed at all.