When rats ate hyaluronic acid, only 16% of it made it into their bloodstream unchanged — the rest got broken down or didn’t get absorbed at all.

When rats were given a special version of hyaluronic acid by mouth, almost all of it left their bodies within a week through breathing, pee, and poop—very little stayed inside, so it didn’t build up.

When you swallow hyaluronic acid, only about 2% of it actually gets into your bloodstream, no matter how big or small the molecules are, because your gut breaks it down too much and doesn’t let much through.

When mice swallow hyaluronan, almost none of it gets into their bloodstream whole—just a tiny bit—so any effects they feel probably come from gut bacteria breaking it down, not from the original substance.

Giving mice a specific type of hyaluronic acid pill every day for a week doesn't make more of it show up in their blood or body tissues compared to mice that just got water.

If you give female mice a special kind of hyaluronic acid pill every day for a week, their bodies end up with more of this substance in their blood and several organs like their skin, eyes, and bladder.