The Claim

Daily supplementation with 5g of TOTUM-63 for 8 weeks in adults with elevated cardiometabolic risk (BMI 31.3±4.1 kg/m², fasting glucose 5.5±0.4 mmol/L) resulted in a statistically significant reduction in HbA1c from 5.5% to 5.3% (p=0.005).

Source: 725-P: TOTUM-63 (T63), a Novel Plant-Based Polyphenol-Rich Substance, Improves Glucose Homeostasis and Modulates Gut Microbiota Diversity among Adults at Increased Cardiometabolic Risk

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
20score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Quantitative
1 study reviewed
In plain English

In adults with elevated cardiometabolic risk, taking 5 grams of TOTUM-63 daily for 8 weeks lowered HbA1c from 5.5% to 5.3%.

See the scientific wording

In a group of 19 adults with elevated cardiometabolic risk (BMI 31.3±4.1 kg/m², fasting glucose 5.5±0.4 mmol/L), daily supplementation with 5g of TOTUM-63 for 8 weeks was followed by a statistically significant reduction in HbA1c from 5.5% to 5.3% (p=0.005), suggesting a potential association between this polyphenol-rich supplement and improved long-term glucose control in this population.

Why this might work

Plant compounds in the supplement feed beneficial gut bacteria, which produce substances that strengthen the gut lining and reduce inflammation. This allows the gut to release hormones that signal the pancreas to release more insulin and the liver to make less sugar, leading to lower average blood sugar levels over time.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: 725-P: TOTUM-63 (T63), a Novel Plant-Based Polyphenol-Rich Substance, Improves Glucose Homeostasis and Modulates Gut Microbiota Diversity among Adults at Increased Cardiometabolic Risk

    In a small study, people with prediabetes and extra weight took a plant-based supplement every day for two months, and their average blood sugar levels (measured by HbA1c) went down a little—but it was a real change, not just luck. This suggests the supplement might help control blood sugar.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.