The Study
725-P: TOTUM-63 (T63), a Novel Plant-Based Polyphenol-Rich Substance, Improves Glucose Homeostasis and Modulates Gut Microbiota Diversity among Adults at Increased Cardiometabolic Risk
This study just watched what happened to 19 people after they took a supplement, but didn't compare them to anyone who didn't take it. So we can't say the supplement caused the changes — maybe they just happened on their own.
Analysis score
Maximum 90 for a randomized controlled trial.
Where the score came from
A daily plant-based pill called TOTUM-63 was given to 19 people with higher risk for heart disease and diabetes to see if it helps their body.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 520 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1These changes are small but statistically meaningful — they suggest the pill may help manage blood sugar and inflammation, which are key for preventing diabetes and heart disease.
- 2After 8 weeks, their HbA1c dropped from 5.5% to 5.3%, inflammation (hs-CRP) went down from 3.3 to 2.5 mg/L, and gut bacteria diversity increased.
- 3After one dose, blood sugar spikes after meals also dropped.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Diabetes
Year
2024
Authors
Annie Bouchard-Mercier, Y. Otero, V. Chavanelle, Julie Marois, G. Pilon, Thibault V. Varin, Patricia L Mitchell, Odd Erik Johansen, M. Bargetto, V. Sapone, F. Le Joubioux, M. Cazaubiel, J. Bard, S. Peltier, P. Couture, M. Vohl, P. Sirvent, André Marette
Related Content
Claims (6)
People who eat 30 or more different types of plants each week have higher gut microbiota diversity than those who eat fewer.
In a group of 19 adults with high cardiometabolic risk, taking 5 grams of TOTUM-63 daily for 8 weeks was linked to measurable decreases in triglycerides, total cholesterol, LDL cholesterol, and the total-C/HDL-C ratio.
In a group of 19 adults with high cardiometabolic risk, taking 5 grams of TOTUM-63 daily for 8 weeks lowered fasting hs-CRP levels from 3.3 mg/L to 2.5 mg/L, a change that was statistically significant.
In a group of 19 adults with elevated cardiometabolic risk, taking 5 grams of TOTUM-63 daily for 8 weeks was associated with a measurable increase in the variety of gut bacteria.
A single 5g dose of TOTUM-63 reduced the peak blood glucose level and the total exposure to the hormone GIP after a meal in 19 adults with elevated cardiometabolic risk.
In adults with elevated cardiometabolic risk, taking 5 grams of TOTUM-63 daily for 8 weeks lowered HbA1c from 5.5% to 5.3%.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.