The Claim

In 19 adults with elevated cardiometabolic risk, daily supplementation with 5g of TOTUM-63 for 8 weeks resulted in a statistically significant reduction in fasting hs-CRP from 3.3 to 2.5 mg/L (p=0.01).

Source: 725-P: TOTUM-63 (T63), a Novel Plant-Based Polyphenol-Rich Substance, Improves Glucose Homeostasis and Modulates Gut Microbiota Diversity among Adults at Increased Cardiometabolic Risk

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
20score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Quantitative
1 study reviewed
In plain English

In a group of 19 adults with high cardiometabolic risk, taking 5 grams of TOTUM-63 daily for 8 weeks lowered fasting hs-CRP levels from 3.3 mg/L to 2.5 mg/L, a change that was statistically significant.

See the scientific wording

In 19 adults with elevated cardiometabolic risk, 8 weeks of daily 5g TOTUM-63 supplementation was followed by a statistically significant reduction in fasting hs-CRP from 3.3 to 2.5 mg/L (p=0.01), suggesting a potential association between this supplement and reduced systemic inflammation in this population.

Why this might work

Plant compounds in the supplement feed beneficial gut bacteria, which produce substances that strengthen the gut lining and reduce leakage of harmful molecules into the blood. This lowers overall body inflammation and improves hormone signals that control blood sugar, leading to less inflammation in the body.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: 725-P: TOTUM-63 (T63), a Novel Plant-Based Polyphenol-Rich Substance, Improves Glucose Homeostasis and Modulates Gut Microbiota Diversity among Adults at Increased Cardiometabolic Risk

    In a small study, 19 people with higher risk for heart disease and diabetes took a plant-based supplement every day for 8 weeks, and their blood test for inflammation went down—meaning the supplement may help reduce body inflammation.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.