In a group of 37 people in Saudi Arabia with a rare cholesterol condition, the most common gene change was in the LDL receptor, which likely breaks how the body clears bad cholesterol — and this...

For people in Saudi Arabia with a rare genetic form of very high cholesterol, taking a drug called evolocumab every two weeks seems to lower their bad cholesterol a little bit — not a huge drop, but enough to show it's doing something.

People with a rare genetic cholesterol disorder who still have a little bit of working cholesterol-cleaning system in their body tend to respond better to a certain type of cholesterol drug, lowering their bad cholesterol by about 20% on average.

People in Saudi Arabia with a rare cholesterol condition don’t seem to lower their bad cholesterol as much with a certain drug as other people did in past studies — and it might be because of their genes or how the treatment is used in real clinics.

For people in Saudi Arabia with a rare inherited form of very high cholesterol, taking a drug called Evolocumab once a month didn’t seem to lower their bad cholesterol much — the drop was small and not strong enough to be sure it wasn’t just by chance.

People with a rare genetic form of high cholesterol caused by two broken copies of the LDLR gene don’t get much benefit from PCSK9 inhibitor drugs — most see almost no drop in their bad cholesterol.