Do cholesterol medicines work as well in everyone?
Effectiveness of PCSK9 inhibitors in homozygous familial hypercholesterolemia: insights from a Saudi Arabia genetic population
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
This study looked at a strong cholesterol medicine given to people from Saudi Arabia with a rare genetic condition that causes very high cholesterol.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 527 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
This study looked at a strong cholesterol medicine given to people from Saudi Arabia with a rare genetic condition that causes very high cholesterol.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 527 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Related Content
Claims (5)
Adding PCSK9 drugs to cholesterol-lowering statins can slash bad cholesterol by as much as 81% in people with high cholesterol.
For people in Saudi Arabia with a rare inherited form of very high cholesterol, taking a drug called Evolocumab once a month didn’t seem to lower their bad cholesterol much — the drop was small and not strong enough to be sure it wasn’t just by chance.
For people in Saudi Arabia with a rare genetic form of very high cholesterol, taking a drug called evolocumab every two weeks seems to lower their bad cholesterol a little bit — not a huge drop, but enough to show it's doing something.
In a group of 37 people in Saudi Arabia with a rare cholesterol condition, the most common gene change was in the LDL receptor, which likely breaks how the body clears bad cholesterol — and this might be common there.
People in Saudi Arabia with a rare cholesterol condition don’t seem to lower their bad cholesterol as much with a certain drug as other people did in past studies — and it might be because of their genes or how the treatment is used in real clinics.