The Claim

In adults with type 2 diabetes, elevated levels of suPAR are associated with the highest relative risk of all-cause mortality among three inflammatory biomarkers, with a 70% mortality rate in the top tertile and 19% in the bottom tertile.

Source: Inflammatory biomarkers suPAR, IL-6, and hsCRP and 13-year risk of mortality and MACE in type 2 diabetes: a prospective cohort study

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
52score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

Among adults with type 2 diabetes, those with the highest levels of suPAR have a 70% chance of dying from any cause during the study period, while those with the lowest levels have a 19% chance.

See the scientific wording

In adults with type 2 diabetes, elevated levels of suPAR are associated with the highest relative risk of all-cause mortality among the three inflammatory biomarkers studied, with a 70% mortality rate in the top tertile compared to 19% in the bottom tertile.

Why this might work

High levels of suPAR activate immune cells, which damage blood vessel walls and cause organs to fail over time, leading to death.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: Inflammatory biomarkers suPAR, IL-6, and hsCRP and 13-year risk of mortality and MACE in type 2 diabetes: a prospective cohort study

    In people with type 2 diabetes, those with the highest levels of a blood marker called suPAR were much more likely to die over 13 years—70% compared to just 19% for those with the lowest levels. The study directly found this.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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