Apigenin suppresses the senescence-associated secretory phenotype (SASP) by inhibiting the secretion of pro-inflammatory cytokines such as IL-6, IL-8, and CXCL10 from senescent cells.

Study: Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells

Apigenin, a natural compound found in some plants, reduces the inflammatory signals released by old, damaged cells without killing them. This helps prevent those cells from causing nearby problems like cancer.

Study: Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts.

Apigenin, a natural compound in plants, was shown to calm down the inflammatory signals that old, tired cells send out — especially IL-6 — in both human cells and aging rats. This means it helps reduce the harmful inflammation linked to aging.

Study: Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Apigenin, a natural compound found in some plants, stops old, damaged cells from sending out harmful inflammatory signals without killing them — like turning down the volume on their noisy behavior.

Study: Apigenin Inhibits the Expression of IL-6, IL-8, and ICAM-1 in DEHP-Stimulated Human Umbilical Vein Endothelial Cells and In Vivo

Apigenin, a natural compound, was shown to reduce two key inflammatory signals (IL-6 and IL-8) in human cells and mice, even when those cells were irritated by a chemical. This suggests it could do the same in aging cells, though the study didn’t test aging cells directly.