The Study
Apigenin Inhibits the Expression of IL-6, IL-8, and ICAM-1 in DEHP-Stimulated Human Umbilical Vein Endothelial Cells and In Vivo
This study tested a plant chemical called apigenin in test tubes and mice to see if it calms down inflammation. It found that it seemed to help in those settings, but we don’t know if it would work in people.
Analysis score
Maximum 58 for a case-control study.
Where the score came from
Scientists tested a natural plant compound called apigenin to see if it could stop inflammation caused by a common plastic chemical (DEHP) in cells and mice.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 512 / 100
Quality score
Researchers compare people who have a condition (cases) with similar people who do not (controls), looking back in time for differences in exposure. Useful but more prone to bias.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes — this suggests apigenin might help reduce allergy and asthma symptoms linked to everyday plastic exposure.
- 2Apigenin lowered levels of three key inflammation signals (IL-6, IL-8, ICAM-1) in human cells and reduced allergic reactions in mice.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Inflammation
Year
2012
Authors
Jia Wang, Yanyan Liao, Jianglin Fan, Ting Ye, Xia Sun, Sijun Dong
Related Content
Claims (6)
Apigenin reduces the release of inflammatory signaling molecules IL-6, IL-8, and CXCL10 from aged, non-dividing cells.
Apigenin reduces the activation of the JNK signaling pathway triggered by DEHP in human endothelial cells, but does not alter IκBα degradation or ERK1/2 phosphorylation.
Apigenin decreases the sticking of immune cells to blood vessel lining cells when those cells are exposed to DEHP, a chemical linked to vascular inflammation.
Apigenin decreases the production of IL-6, IL-8, and ICAM-1 in live mice exposed to compound 48/80, demonstrating anti-inflammatory activity beyond cell-based experiments.
Apigenin reduces the severity of systemic allergic reactions triggered by compound 48/80 in mice.
Apigenin lowers the levels of IL-6, IL-8, and ICAM-1 molecules in human blood vessel cells exposed to DEHP, a common environmental chemical.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.