At the start of the study, people with HIV who had denser thigh muscles also had lower levels of certain inflammation markers, like TNF-alpha and IL-6.

Scientific Claim

At baseline, muscle density was inversely correlated with tumor necrosis factor alpha and IL-6 levels in older adults with HIV.

Original Statement

“At baseline, muscle density significantly correlated inversely with tumor necrosis factor alpha and IL-6.”

From study:Randomized Clinical Trial of High Intensity Exercise in People with HIV: Effects on Muscle Composition and Inflammation.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim correctly states the observed correlation without implying causation, which is appropriate for this type of data.

Evidence from Studies

Supporting (1)

Randomized Clinical Trial of High Intensity Exercise in People with HIV: Effects on Muscle Composition and Inflammation.

Randomized Controlled Trial

Human

2025 May 8

Contradicting (0)

No contradicting evidence found

Source Study

Randomized Clinical Trial of High Intensity Exercise in People with HIV: Effects on Muscle Composition and Inflammation.

Score: 47

DOI: 10.1097/QAI.0000000000003692

Similar Assertions

Older adults with HIV who exercised for 16 weeks likely had denser thigh muscles (5.2% increase) compared to the control group (0.3% decrease), which was statistically significant.

77%

Older people with HIV who did aerobic and resistance exercise for 16 weeks probably had bigger thigh muscles (7.5% increase) compared to those who didn't (3.1% decrease), and this difference was statistically significant.

71%