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Claim
Strong Support
descriptive
Analysis v3

Before treatment began, people given vitamin D by mouth had the same average blood levels of vitamin D as people given vitamin D by injection.

54
Pro
0
Against

Mechanism

Synthesis from 1 study

How it works

Whether vitamin D is given as a pill or a shot, the body turns it into the same molecule in the liver, so blood levels start out the same before treatment. The route doesn't change how the body processes it, only how quickly it gets there.

Most probable mechanism

In Simple Terms

When vitamin D is given by mouth or injection, it enters the bloodstream and travels to the liver, where it is changed into a form called 25-hydroxyvitamin D. This form is what doctors measure in the blood to check vitamin D levels, and it is the same whether the vitamin D came from a pill or a shot.

Causal chain
1

Vitamin D3 is absorbed into the bloodstream from the gastrointestinal tract after oral administration or from muscle tissue after intramuscular injection

Verified by multiple studies
which leads to
2

Vitamin D3 is transported via the bloodstream to the liver

Verified by multiple studies
which leads to
3

In the liver, vitamin D3 is converted by the enzyme 25-hydroxylase into 25-hydroxyvitamin D3, the primary circulating form measured in serum

Verified by multiple studies
which leads to
4

Serum concentrations of 25-hydroxyvitamin D3 reflect the total body vitamin D status and are identical regardless of the route of administration when baseline levels are equivalent

Verified by multiple studies

Evidence from Studies

Supporting (1)

54

Community contributions welcome

54

Comparison of the Effect of Oral Versus Parenteral Vitamin D on Serum Levels of Vitamin D in Premature Infants with Vitamin D Deficiency

Randomized Controlled Trial
Human

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

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Source Study

Comparison of the Effect of Oral Versus Parenteral Vitamin D on Serum Levels of Vitamin D in Premature Infants with Vitamin D Deficiency

Score: 54
DOI: 10.5812/compreped-134297

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