In rats with kidney problems, blocking a specific protein receptor stops kidney damage caused by acidic diets, showing this receptor is important for acid-related kidney harm.

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Pro

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Evidence from Studies

Supporting (1)

6

Community contributions welcome

6

Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors.

Cohort Study

Animal

2008 Jan

The study gave rats a special medicine that blocks endothelin A receptors and found it stopped kidney damage from acidic diets, which is exactly what the claim said would happen.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors.

Score: 6

DOI: 10.1038/SJ.KI.5002647

Similar Assertions

Eating a protein called casein makes rats with damaged kidneys sicker by making their blood too acidic and slowly worsening their kidney function, and this happens because of a specific part in their body called endothelin A receptors.

6

0

84%

In rats, male kidneys make more endothelin-1 when they eat salt—but in humans, it’s the opposite: female kidneys make more. This shows we can’t just assume animal results apply to people.

56

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70%