How different foods affect rat kidneys
Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 56 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 56 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Publication
Journal
Kidney international
Year
2008
Authors
S. Phisitkul, C. Hacker, J. Simoni, R. Tran, D. Wesson
Related Content
Claims (6)
Eating a lot of protein might put extra strain on your kidneys, which could be harmful over time.
Eating a protein called casein makes rats with damaged kidneys sicker by making their blood too acidic and slowly worsening their kidney function, and this happens because of a specific part in their body called endothelin A receptors.
When rats with damaged kidneys eat a soy protein diet with extra acid added, it makes their blood too acidic and worsens their kidney function, showing that the acid causes the kidneys to work less well.
In rats with kidney problems, blocking a specific protein receptor stops kidney damage caused by acidic diets, showing this receptor is important for acid-related kidney harm.
Giving baking soda in food helps fix acid problems and protects kidney function in rats with damaged kidneys, but only if you first handle the high blood pressure that baking soda can cause.