Scientists found that a specific signaling pathway called ERK1/2 is responsible for how blood flow changes affect an enzyme that controls nitric oxide production, and blocking this pathway stops the negative effects of low blood flow on nitric oxide.

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Supporting (1)

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4

Modulation of low shear stress-induced eNOS multi-site phosphorylation and nitric oxide production via protein kinase and ERK1/2 signaling

Cross-Sectional Study

In Vitro

2017 Feb

The study shows that when endothelial cells are exposed to low shear stress (like in areas prone to atherosclerosis), the ERK1/2 pathway triggers a specific phosphorylation of eNOS that reduces nitric oxide production. When researchers blocked ERK1/2 with a specific inhibitor, this completely prevented the drop in nitric oxide, supporting the claim.

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Source Study

Modulation of low shear stress-induced eNOS multi-site phosphorylation and nitric oxide production via protein kinase and ERK1/2 signaling

Score: 4

DOI: 10.3892/mmr.2016.6060

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