Scientists found that a compound called 8-Bromo-cAMP can help restore a key process in blood vessel cells that makes nitric oxide (a molecule that helps blood vessels work properly) when blood flow is too weak.

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Evidence from Studies

Supporting (1)

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Modulation of low shear stress-induced eNOS multi-site phosphorylation and nitric oxide production via protein kinase and ERK1/2 signaling

Cross-Sectional Study

In Vitro

2017 Feb

The study shows that applying 8-Bromo-cAMP to endothelial cells under low shear stress conditions reverses the damage - it restores the eNOS-Ser633 phosphorylation that was blocked and partially prevents the drop in nitric oxide production. This directly confirms the claim.

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Source Study

Modulation of low shear stress-induced eNOS multi-site phosphorylation and nitric oxide production via protein kinase and ERK1/2 signaling

Score: 4

DOI: 10.3892/mmr.2016.6060

Similar Assertions

Scientists found that a specific signaling pathway called ERK1/2 is responsible for how blood flow changes affect an enzyme that controls nitric oxide production, and blocking this pathway stops the negative effects of low blood flow on nitric oxide.

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77%

When blood vessels experience low blood flow (low shear stress), a protein called Akt helps trigger a process that produces nitric oxide, which keeps blood vessels healthy. But when we block Akt, the blood vessel's ability to produce nitric oxide gets even worse.

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74%