In mice, blocking two specific signals in the body (IL-6 and JNK) fixes blood sugar problems, fatty liver, and insulin resistance caused by a keto diet—basically undoing those issues in just 3 days.

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Evidence from Studies

Supporting (1)

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A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice

Cross-Sectional Study

Animal

2023 Mar

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

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Source Study

A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice

Score: 13

DOI: 10.1016/j.molmet.2023.101675

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In mice, eating a keto diet for just 3 days seems to raise a certain protein linked to inflammation, especially from belly fat, which might lead to liver problems and trouble using insulin.

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In mice, going on a keto diet for just 3 days seems to make their livers less responsive to insulin—even though their blood sugar is lower—suggesting early signs of metabolic problems.

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