In mice, going on a keto diet for just 3 days seems to make their livers less responsive to insulin—even though their blood sugar is lower—suggesting early signs of metabolic problems.

Pro

Against

Evidence from Studies

Supporting (1)

Community contributions welcome

A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice

Cross-Sectional Study

Animal

2023 Mar

Contradicting (0)

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice

Score: 13

DOI: 10.1016/j.molmet.2023.101675

Similar Assertions

In mice, blocking two specific signals in the body (IL-6 and JNK) fixes blood sugar problems, fatty liver, and insulin resistance caused by a keto diet—basically undoing those issues in just 3 days.

76%

If you're an adult with mild type 2 diabetes, switching to a keto diet for 12 weeks might lower a fat in your blood linked to liver fat, more than a low-fat diet would.

71%