Blocking a protein called SIRT5 helps liver cells keep their energy and internal balance healthy when they're overwhelmed with fat.

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Evidence from Studies

Supporting (1)

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SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.

Cross-Sectional Study

Human & In Vitro

2024 Jan

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No contradicting evidence found

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Source Study

SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.

Score: 42

DOI: 10.1016/j.jhep.2023.09.020

Similar Assertions

If someone with fatty liver disease has a certain gene variant (SIRT5 G allele), their liver cells might show more activity in energy-producing parts, higher levels of damaging stress chemicals, and less energy available overall.

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