A gene change makes liver disease worse
SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A small change in a gene called SIRT5 is linked to worse liver damage in people with fatty liver disease. This change makes the energy factories in liver cells work poorly and creates more harmful chemicals.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
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Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A small change in a gene called SIRT5 is linked to worse liver damage in people with fatty liver disease. This change makes the energy factories in liver cells work poorly and creates more harmful chemicals.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 542 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Publication
Authors
Salomone F, Pipitone RM, Longo M, Malvestiti F, Amorini AM, Distefano A, Casirati E, Ciociola E, Iraci N, Leggio L, Zito R, Vicario N, Saoca C, Pennisi G, Cabibi D, Lazzarino G, Fracanzani AL, Dongiovanni P, Valenti L, Petta S, Volti GL, Grimaudo S
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Claims (3)
A certain gene change (SIRT5 rs12216101) might make it more likely for some Europeans with fatty liver disease to develop serious liver inflammation and scarring, even after accounting for other known risk factors.
If someone with fatty liver disease has a certain gene variant (SIRT5 G allele), their liver cells might show more activity in energy-producing parts, higher levels of damaging stress chemicals, and less energy available overall.
Blocking a protein called SIRT5 helps liver cells keep their energy and internal balance healthy when they're overwhelmed with fat.