The Study
SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.
This study looks at whether a certain gene variant is linked to worse liver disease in people who already have fatty liver. It can show a connection, but it can't prove that the gene variant causes the damage — other factors might be involved.
Analysis score
Maximum 44 for a cross-sectional study.
Where the score came from
A small change in a gene called SIRT5 is linked to worse liver damage in people with fatty liver disease. This change makes the energy factories in liver cells work poorly and creates more harmful chemicals.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 542 / 100
Quality score
Snapshots of a population at a single point in time, or descriptions of small groups. Can identify correlations and prevalence, but cannot determine cause and effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1This gene change may make fatty liver disease progress faster in some people, and a drug that blocks SIRT5 might help protect the liver.
- 2People with the G version of the gene had 20% higher chance of liver inflammation and 18% higher chance of serious scarring.
- 3Their liver cells showed more stress and less energy.
- 4In lab tests, blocking the SIRT5 gene helped protect liver cells.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Journal of hepatology
Year
2023
Authors
F. Salomone, R. Pipitone, F. Malvestiti, Miriam Longo, A. M. Amorini, A. Distefano, E. Casirati, E. Ciociola, N. Iraci, Loredana Leggio, R. Zito, N. Vicario, Concetta Saoca, G. Pennisi, D. Cabibi, G. Lazzarino, A. Fracanzani, P. Dongiovanni, L. Valenti, S. Petta, Giovanni Li Volti, S. Grimaudo
Related Content
Claims (3)
A certain gene change (SIRT5 rs12216101) might make it more likely for some Europeans with fatty liver disease to develop serious liver inflammation and scarring, even after accounting for other known risk factors.
If someone with fatty liver disease has a certain gene variant (SIRT5 G allele), their liver cells might show more activity in energy-producing parts, higher levels of damaging stress chemicals, and less energy available overall.
Blocking a protein called SIRT5 helps liver cells keep their energy and internal balance healthy when they're overwhelmed with fat.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.