If someone with fatty liver disease has a certain gene variant (SIRT5 G allele), their liver cells might show more activity in energy-producing parts, higher levels of damaging stress chemicals, and...

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SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.

Cross-Sectional Study

Human & In Vitro

2024 Jan

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No contradicting evidence found

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Source Study

SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.

Score: 42

DOI: 10.1016/j.jhep.2023.09.020

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Blocking a protein called SIRT5 helps liver cells keep their energy and internal balance healthy when they're overwhelmed with fat.

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A certain gene change (SIRT5 rs12216101) might make it more likely for some Europeans with fatty liver disease to develop serious liver inflammation and scarring, even after accounting for other known risk factors.

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