A certain gene change (SIRT5 rs12216101) might make it more likely for some Europeans with fatty liver disease to develop serious liver inflammation and scarring, even after accounting for other...

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SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.

Cross-Sectional Study

Human & In Vitro

2024 Jan

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Source Study

SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.

Score: 42

DOI: 10.1016/j.jhep.2023.09.020

Similar Assertions

If someone with fatty liver disease has a certain gene variant (SIRT5 G allele), their liver cells might show more activity in energy-producing parts, higher levels of damaging stress chemicals, and less energy available overall.

74%

In very overweight people, those with the worst fatty liver also had much lower levels of a specific gene (SIRT1) in their belly fat, which might mean this gene helps protect the liver from too much fat.

72%

In very overweight people, only the fat around the organs (not the fat under the skin or back) shows lower levels of a protective gene (SIRT1) when the liver is very fatty — suggesting belly fat is uniquely involved.

71%