Some supplements might help your body process estrogen in a safer way, potentially lowering the risk of certain health issues.

49

Pro

54

Against

Evidence from Studies

Supporting (1)

49

Community contributions welcome

49

The impact of 3,3’-diindolylmethane on estradiol and estrogen metabolism in postmenopausal women using a transdermal estradiol patch

Cohort Study

Human

2025 Jul 1

The study found that taking a supplement called DIM changed how the body processes estrogen in a way that may be healthier. This supports the idea that some supplements can help steer estrogen down safer paths.

Contradicting (1)

54

Community contributions welcome

54

Effectiveness of 3,3′-Diindolylmethane Supplements on Favoring the Benign Estrogen Metabolism Pathway and Decreasing Body Fat in Premenopausal Women

Randomized Controlled Trial

Human

2023

The study tested a supplement called DIM to see if it helps the body process estrogen in a safer way, but it didn’t find strong proof that it worked.

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Similar Assertions

If postmenopausal women using estrogen patches also take a supplement called DIM, it might change how their body processes estrogen—lowering some types linked to higher risk and raising others that may be safer.

49

0

72%

Taking a daily supplement with certain plant compounds might help your body process estrogen in a healthier way, which could lower the risk of some hormone-related cancers in women, whether or not they’ve gone through menopause.

69

0

71%