A modified version of the GIP hormone, with a change at position 2, produces a weaker insulin response than the natural form, indicating that this change interferes with how the hormone activates its...

Pro

Against

Evidence from Studies

Supporting (1)

Community contributions welcome

Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid.

Randomized Controlled Trial

Animal & In Vitro

2004 Aug 15

Contradicting (0)

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid.

Score: 12

DOI: 10.1016/J.ABB.2004.05.005

Similar Assertions

Modified versions of GLP-1 and GIP hormones that resist breakdown by DPP IV lower blood glucose more effectively in diabetic mice than the natural versions, and the location of a specific amino acid change (Abu8 in GLP-1) results in the strongest effect.

72%