Modified versions of GLP-1 and GIP hormones that resist breakdown by DPP IV lower blood glucose more effectively in diabetic mice than the natural versions, and the location of a specific amino acid...

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Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid.

Randomized Controlled Trial

Animal & In Vitro

2004 Aug 15

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Source Study

Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid.

Score: 12

DOI: 10.1016/J.ABB.2004.05.005

Similar Assertions

In mice with obesity and diabetes, a modified version of the hormone GLP-1 called (Abu8)GLP-1 lowers blood sugar and increases insulin production more than two other related hormones, suggesting this chemical change improves its ability to act against diabetes in living organisms.

83%

GLP-1 and GIP are hormones that increase insulin production and decrease glucagon production when nutrients are consumed, which helps control blood glucose levels.

75%

A modified version of the GIP hormone, with a change at position 2, produces a weaker insulin response than the natural form, indicating that this change interferes with how the hormone activates its receptor, even though it makes the hormone more resistant to breakdown.

72%