Chronically elevated copeptin levels are associated with a significantly increased risk of developing type 2 diabetes.

Study: Copeptin, Insulin Resistance, and Risk of Incident Diabetes in Older Men

People with higher levels of a body chemical called copeptin — which often means they’re dehydrated — were much more likely to develop type 2 diabetes over time, even after accounting for other risk factors like weight and blood sugar.

Study: Sex differences in the association between plasma copeptin and incident type 2 diabetes: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study

People with higher levels of a substance called copeptin in their blood are more likely to develop type 2 diabetes later on, especially women. This study found that copeptin can help predict who might get diabetes, even better than some other common tests.

Study: Copeptin as a dual biomarker in type 2 diabetes: association with glycemic control and diabetic kidney disease

People with type 2 diabetes have much higher levels of a substance called copeptin in their blood than people without diabetes. This suggests that high copeptin might be a sign that someone is more likely to develop diabetes.

Study: The Impact of Hydration on Metabolic Outcomes: From Arginine-Vasopressin Signaling to Clinical Implications

When your body is dehydrated, it releases a hormone that also affects how your body handles sugar. This study shows that when this hormone stays high for a long time, it’s linked to a higher chance of getting type 2 diabetes — and copeptin is a marker that tells us when this hormone is high.