Doing multiple different exercises with higher volume does not lead to noticeably more muscle growth than doing just one exercise four times per week.
Mechanism
Synthesis from 2 studies
Muscles grow when they’re pulled hard enough during lifting. If you lift the same total weight—no matter if you use one exercise or many—you’re already pulling your muscles as hard as they need to be pulled to grow. Adding more exercises or more sets doesn’t help if you’re not pulling harder...
Most probable mechanism
When you lift weights, your muscles grow because the fibers are stretched and pulled hard enough to trigger repair and thickening. If you do one exercise with enough total weight lifted, you already stretch and pull all the fibers in that muscle just as much as if you did many different exercises. Adding more exercises or more sets doesn’t help if the total pulling force on the fibers stays the same.
Mechanical tension applied to muscle fibers during resistance exercise activates signaling pathways that stimulate protein synthesis and muscle fiber enlargement
When total mechanical load (volume × intensity) is held constant across different training protocols, the magnitude of muscle fiber tension and subsequent signaling remains similar regardless of exercise variety or set distribution
Increasing the number of sets or exercises without increasing total mechanical load does not elevate muscle fiber tension beyond the threshold required to maximize protein synthesis and hypertrophic signaling
Evidence from Studies
Supporting (2)
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Contradicting (0)
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Gold Standard Evidence Needed
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