The Claim
Pretreatment with 10 mM creatine or 5 mM nicotinamide preserves IGF-1 mRNA and protein levels in human dermal fibroblasts exposed to 600 µM hydrogen peroxide, suggesting these compounds may help maintain paracrine signaling from fibroblasts to keratinocytes under oxidative stress conditions.
What the research says
Roughly balanced
Support and challenge are close. The picture may shift as more studies come in.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Taking creatine or nicotinamide before skin cells are stressed by harmful molecules might help keep them talking to neighboring skin cells, which could support skin health when under stress.
See the scientific wording
Pretreatment with 10 mM creatine or 5 mM nicotinamide is associated with preservation of IGF-1 mRNA and protein levels in human dermal fibroblasts exposed to 600 µM hydrogen peroxide, suggesting these agents may help maintain paracrine signaling to keratinocytes under oxidative stress.
What the research says
1 studyStudy: Creatine and Nicotinamide Prevent Oxidant-Induced Senescence in Human Fibroblasts
The study shows that creatine and nicotinamide help skin cells keep making a growth signal (IGF-1) when stressed, which supports the idea that they protect skin cell communication.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.