Taking creatine or nicotinamide before skin cells are stressed by harmful molecules might help keep them talking to neighboring skin cells, which could support skin health when under stress.

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Pro

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Against

Evidence from Studies

Supporting (1)

4

Community contributions welcome

4

Creatine and Nicotinamide Prevent Oxidant-Induced Senescence in Human Fibroblasts

Cross-Sectional Study

In Vitro

2021 Nov 16

The study shows that creatine and nicotinamide help skin cells keep making a growth signal (IGF-1) when stressed, which supports the idea that they protect skin cell communication.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Creatine and Nicotinamide Prevent Oxidant-Induced Senescence in Human Fibroblasts

Score: 4

DOI: 10.3390/nu13114102

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