The Study
Creatine and Nicotinamide Prevent Oxidant-Induced Senescence in Human Fibroblasts
We couldn't fully understand what type of study this is, so we're being extra careful about what conclusions to draw from it.
Analysis score
Maximum 44 for a cross-sectional study.
Where the score came from
This study checks if two energy-boosting chemicals can stop skin support cells from aging too fast when stressed by harmful molecules.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 54 / 100
Quality score
Snapshots of a population at a single point in time, or descriptions of small groups. Can identify correlations and prevalence, but cannot determine cause and effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1This suggests these chemicals might help older skin stay healthier if used before damage occurs, but won’t fix already aged cells.
- 2Cells treated with creatine or nicotinamide before stress had 10–50% less aging signs and lower inflammation and damage markers.
- 3The same treatment after stress did nothing.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Nutrients
Year
2021
Authors
A. S. Mahajan, V. Arikatla, A. Thyagarajan, Tetyana Zhelay, R. Sahu, M. Kemp, D. Spandau, J. Travers
Related Content
Claims (5)
Taking creatine or nicotinamide before skin cells are stressed by harmful molecules might help keep them talking to neighboring skin cells, which could support skin health when under stress.
Taking creatine or nicotinamide before damage from hydrogen peroxide might help skin cells stay healthier longer by reducing signs of aging in the lab.
Taking creatine or nicotinamide before damage might help protect skin cells from stress and aging by reducing harmful molecules called free radicals.
Taking creatine or nicotinamide before skin cells are stressed might help reduce inflammation, based on lab studies with human skin cells.
After skin cells are damaged, taking creatine or a form of vitamin B3 doesn’t seem to help them recover or become less aged, based on lab tests.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.