After skin cells are damaged, taking creatine or a form of vitamin B3 doesn’t seem to help them recover or become less aged, based on lab tests.

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Evidence from Studies

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Contradicting (1)

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Creatine and Nicotinamide Prevent Oxidant-Induced Senescence in Human Fibroblasts

Cross-Sectional Study

In Vitro

2021 Nov 16

The study found that giving creatine or nicotinamide *after* hydrogen peroxide damage didn’t help fix the aged cells, which matches the claim.

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Creatine and Nicotinamide Prevent Oxidant-Induced Senescence in Human Fibroblasts

Score: 4

DOI: 10.3390/nu13114102

Similar Assertions

Taking creatine or nicotinamide before damage from hydrogen peroxide might help skin cells stay healthier longer by reducing signs of aging in the lab.

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Taking creatine or nicotinamide before damage might help protect skin cells from stress and aging by reducing harmful molecules called free radicals.

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Taking creatine or nicotinamide before skin cells are stressed might help reduce inflammation, based on lab studies with human skin cells.

4

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