Taking 20 grams of creatine daily for two weeks causes platelets in the blood to become more active in healthy people.
From A New Study Just Linked Creatine To Cancer · videoSee the scientific wording
Creatine supplementation at a dosage of 20 g per day for two weeks induces platelet hyperactivation in healthy humans.
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Taking 20 grams of creatine daily for two weeks causes platelets in the blood to become more active in healthy people.
Evidence from Studies
Last searched 2mo ago
No evidence studies found yet.
What Would Prove This
Per GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this claim, ordered from strongest to weakest.
Systematic Review of RCTs on Creatine Supplementation and Platelet Activation
Systematic search of databases for double-blind, placebo-controlled RCTs in healthy adults using creatine at ≥20 g/day for ≥2 weeks, measuring platelet activation markers (e.g., P-selectin, platelet aggregation) as primary outcome. Meta-analysis if heterogeneity allows.
Double-Blind Placebo-Controlled RCT of High-Dose Creatine on Platelet Function
Parallel-group, placebo-controlled, double-blind RCT in 100 healthy adults (50 per group). Intervention: 20 g/day creatine monohydrate for 14 days. Control: matched placebo (e.g., maltodextrin). Primary outcome: change in platelet aggregation response to ADP and collagen. Secondary: P-selectin expression, thromboxane B2 levels.
Prospective Cohort Study of Creatine Use and Platelet Activation in Athletes
Prospective cohort of 500 healthy athletes aged 18-40. Baseline platelet function tests (aggregation, P-selectin). Self-report creatine use (dose and duration). Follow-up at 2, 4, 8 weeks with repeat platelet testing. Multivariable regression adjusting for confounders (age, sex, exercise, diet).
In Vitro Study of Creatine's Direct Effect on Human Platelet Aggregation
Incubate human platelet-rich plasma (PRP) from healthy donors with varying concentrations of creatine (0-20 mM, reflecting physiologic and supraphysiologic levels). Measure platelet aggregation in response to agonists (ADP, collagen, thrombin) by light transmission aggregometry. Also measure ATP release and calcium mobilization.