Cutting off oxygen and sugar from eye cells for 6 hours kills more than 40% of them—making it a reliable lab way to mimic stroke-like damage.
Scientific Claim
In avian retinal cell cultures, oxygen-glucose deprivation for 6 hours reduces cell viability to 58% of control levels, establishing a reproducible in vitro model of ischemic stress for neuroprotection studies.
Original Statement
“OGD caused a significant reduction in cell viability in all periods of exposure: 3 h (80.0% ± 2.10%)... 6 h (58% ± 4.60%)... and 24 h (62% ± 2.50%), compared to the control group.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The model’s effect is directly measured and reproducible; the claim describes an observed outcome without implying causation beyond the experimental conditions.
Evidence from Studies
Supporting (1)
Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection
This study used a common lab method to stress retinal cells by cutting off oxygen and sugar, which made the cells weaker — just like the claim says. It didn’t give the exact number (58%), but it proved the method works to study how to protect these cells.