When eye cells are starved of oxygen and sugar, their natural defense system weakens—but this compound can help restore part of it, at least in the first few hours.
Scientific Claim
Catalase activity in avian retinal cells is significantly reduced after 3 hours of oxygen-glucose deprivation (to 56% of control), and this reduction is partially reversed by Brosimine B at 10 µM, suggesting oxidative stress impairs endogenous antioxidant defenses early in ischemia.
Original Statement
“After 3 h of OGD, catalase activity was significantly reduced (56.20% ± 6.11%)... treatment with 10 μM of Brosimine B caused a significant increase in catalase activity (124.00% ± 17.20%) compared to both the control and OGD groups.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study observes association between treatment and enzyme activity change; it does not prove Brosimine B directly activates catalase. 'Suggesting' appropriately reflects inferential reasoning.
Evidence from Studies
Supporting (1)
Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection
The study shows that a natural compound called Brosimine B, at a specific dose, helps protect eye cells from damage caused by lack of oxygen and sugar, likely by boosting a key antioxidant enzyme called catalase.