At the right dose, this compound can reduce harmful stress molecules in eye cells—but only if given right after the stress starts, not later.
Scientific Claim
Brosimine B at 10 µM is associated with a 27% reduction in reactive oxygen species (ROS) in retinal cells exposed to 3 hours of oxygen-glucose deprivation, but shows no significant effect at 6 or 24 hours, indicating a time-limited antioxidant effect.
Original Statement
“Administration of 10 µM of Brosimine B to retinal cell cultures submitted to OGD decreased ROS levels, but only in the 3 h period after induction of hypoxia (269.00% ± 54.00%; Interaction 19.64, ### p < 0.0001)... with no effect being observed for the 6 h... and 24 h period.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study measures association between compound exposure and ROS levels in a controlled cell model; no causal mechanism is proven. 'Associated with' is appropriate given the non-causal design.
Evidence from Studies
Supporting (0)
Contradicting (1)
Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection
The study says Brosimine B at a certain dose helps reduce harmful molecules in eye cells during oxygen shortage, but it didn’t check if this effect lasts 6 or 24 hours, so we can’t say it’s only short-term.