This compound can help eye cells survive short-term oxygen loss, but loses its power if the stress lasts too long.

Scientific Claim

Brosimine B at 10 µM is associated with partial restoration of retinal cell viability during oxygen-glucose deprivation at 3 and 6 hours, but not at 24 hours, indicating a time-dependent protective effect in ischemic conditions.

Original Statement

“After the addition of 10 µM of Brosimine B to OGD cell cultures, cell viability increased after a period of 3 h (107.00% ± 6.20%; ### p < 0.0001) and 6 h (25.00% ± 0.70%; ## p < 0.001), but not 24 h (39.00% ± 1.40%; ns; Interaction:13.00).”

From study:Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study observes temporal associations between treatment and viability outcomes but cannot establish causation or biological reason for the time dependency. 'Associated with' is appropriate.

Evidence from Studies

Supporting (1)

Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

Cross-Sectional Study

Animal

At a low dose, Brosimine B helps retinal cells survive short-term oxygen and sugar loss, but this help doesn’t last all day — it fades after 24 hours, which matches the claim.

Contradicting (0)

No contradicting evidence found

Source Study

Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

Score: 12

DOI: 10.3389/fphar.2025.1558726

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