Analysis Version
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Back to Study: Brosimine B and the biphasic dose-response: insigh...
mechanistic
Analysis v1
12
Pro
0
Against

This compound helps eye cells make more of a natural 'clean-up' enzyme that fights harmful chemicals, but only if given early after stress begins.

Scientific Claim

Brosimine B at 10 µM is associated with a 124% increase in catalase enzyme activity in retinal cells after 3 hours of oxygen-glucose deprivation, suggesting enhancement of endogenous antioxidant defenses as a potential mechanism of protection.

Original Statement

“Treatment with 10 μM of Brosimine B caused a significant increase in catalase activity (124.00% ± 17.20%; Interaction 26.11, ***p < 0.001) compared to both the control and OGD groups (Figure 6A).”

From study:Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

While catalase activity is measured directly, the study cannot prove Brosimine B causes increased activity—it only shows association. 'Associated with' is correct for this design.

Evidence from Studies

Supporting (1)

12
12

Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

Cross-Sectional Study
Animal

The study shows that a small amount of Brosimine B helps protect eye cells from damage during oxygen shortage by boosting their natural defense system, including an enzyme called catalase—even if it doesn’t give the exact 124% number, the overall idea is backed up.

Contradicting (0)

0
No contradicting evidence found

Source Study

Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

Score: 12
DOI: 10.3389/fphar.2025.1558726

Similar Assertions

This compound helps eye cells fight stress for a few hours, but after a full day, it stops working—so it won’t help if the damage lasts too long.

0
12
92%

At the right dose, this compound can reduce harmful stress molecules in eye cells—but only if given right after the stress starts, not later.

0
12
85%

When eye cells are starved of oxygen and sugar, their natural defense system weakens—but this compound can help restore part of it, at least in the first few hours.

12
0
84%

This compound can help eye cells survive short-term oxygen loss, but loses its power if the stress lasts too long.

12
0
83%

A natural compound called Brosimine B helps retinal cells survive better at a very specific low dose, but hurts them if you give too much.

0
12
81%