This compound helps eye cells fight stress for a few hours, but after a full day, it stops working—so it won’t help if the damage lasts too long.

Scientific Claim

Brosimine B does not significantly alter catalase activity in avian retinal cells after 24 hours of oxygen-glucose deprivation, indicating that its antioxidant-enhancing effects are transient and may not sustain protection during prolonged ischemic stress.

Original Statement

“After 24 h of OGD, catalase activity was similarly decreased in both treated (63.30% ± 14.36%) and untreated groups (67.20% ± 7.85%), compared to controls (100.00% ± 20.40%), with no significant difference (ns, p > 0.05).”

From study:Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The absence of effect is statistically reported as non-significant; the claim accurately reflects the data without overinterpreting the mechanism.

Evidence from Studies

Supporting (0)

No supporting evidence found

Contradicting (1)

Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

Cross-Sectional Study

Animal

The study found that Brosimine B helps protect eye cells from damage during oxygen and sugar shortage by boosting natural antioxidant defenses, including catalase — so it does work, and it works for at least 24 hours, contrary to the claim.

Source Study

Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

Score: 12

DOI: 10.3389/fphar.2025.1558726

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