A plant chemical that helps cells at just the right dose
Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
The hormetic curve was modeled with near-perfect accuracy (R² = 0.984), meaning the inverted U-shape wasn’t just a trend—it was mathematically predictable.
Most natural compounds have messy, unpredictable dose responses. This one’s so clean it could be used to design future drugs with exact dosing algorithms.
Practical Takeaways
Avoid unregulated supplements claiming 'Brosimine B' or 'Mururé bark extract'—there’s no safe human dose yet.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
The hormetic curve was modeled with near-perfect accuracy (R² = 0.984), meaning the inverted U-shape wasn’t just a trend—it was mathematically predictable.
Most natural compounds have messy, unpredictable dose responses. This one’s so clean it could be used to design future drugs with exact dosing algorithms.
Practical Takeaways
Avoid unregulated supplements claiming 'Brosimine B' or 'Mururé bark extract'—there’s no safe human dose yet.
Publication
Journal
Frontiers in Pharmacology
Year
2025
Authors
Susanne Suely Santos da Fonseca, Natacha M. S. Port’s, Gisele Priscila Soares de Aguiar, Eliã P. Botelho, Nádia M. G. Couto, W. B. S. Pinheiro, André Salim Khayat, Elizabeth S. Yamada, Edmar T. Costa, C. B. C. Sena, Mara Silvia P. Arruda, C. P. Bahia, Antonio Pereira
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Claims (10)
This compound works best at one very specific dose—too little does nothing, too much hurts—and scientists can predict this pattern very accurately with math.
This compound helps eye cells make more of a natural 'clean-up' enzyme that fights harmful chemicals, but only if given early after stress begins.
This compound only works if you give it at just the right amount—too little or too much doesn’t help, so getting the dose exactly right is super important.
Cutting off oxygen and sugar from eye cells for 6 hours kills more than 40% of them—making it a reliable lab way to mimic stroke-like damage.
When eye cells are starved of oxygen and sugar, their natural defense system weakens—but this compound can help restore part of it, at least in the first few hours.